Comments on: The E2 Mechanism https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/ Sat, 02 May 2026 03:05:14 +0000 hourly 1 https://wordpress.org/?v=6.9.4 By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-779664 Thu, 06 Nov 2025 19:42:35 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-779664 In reply to G.

Great catch, thank you! Corrected!

]]> By: G https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-779571 Thu, 06 Nov 2025 08:20:13 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-779571 “Aprotic solvents are actually not ideal, since they can hydrogen bond with the base and ‘buffer’ it, reducing its activity. Fig. 4 and Table VI illustrate the dramatic dependence of base activity on the percentage of DMSO in the solvent system.” (from the references)

Should this say protic solvents are not ideal for E2?

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-754089 Fri, 20 Jun 2025 10:06:23 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-754089 In reply to 1001000100001110 0011100101100111100101110.

Explain?

]]> By: 1001000100001110 0011100101100111100101110 https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-751605 Sun, 15 Jun 2025 17:51:35 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-751605 Fun when your own house is the target of “explained information”

]]> By: Ayushi Chaudhary https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-686557 Mon, 04 Mar 2024 17:18:35 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-686557 Hello sir
In bromocyclohexane , if at one ortho position bromine is anti-periplaner with hydrogen and on the other ortho, with Deuterium then which will be a fovoured (major) compound formed ??

]]> By: hans https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-655411 Thu, 18 May 2023 13:54:40 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-655411 Is a big benefits to read this O-Chem site.

]]> By: James Ashenhurst https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-639975 Mon, 10 Oct 2022 17:20:38 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-639975 In reply to Sundar Naga.

I agree that a mechanism is a theory, and theories help us make sense of facts that are observed. I also think that theories can never be proven, only disproven.

When I use the word “clue”, I am using it somewhat colloquially as a synonym for “evidence”. The rate law represents experimental data that any postulated mechanism has to be consistent with.

I don’t really see a problem with using the word “clue” here. Facts are clues. Figuring out a mechanism can be a bit like figuring out a puzzle. Based on what I’m reading in your comment, I don’t see a good enough reason to replace the word.

]]> By: Sundar Naga https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-639808 Sat, 08 Oct 2022 12:41:33 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-639808 I have been a big fan of Master Organic Chemistry. You are doing a great job. Just wanted to point out something very important. The reason for chemists imagining a possible mechanism for a given type of reaction is to explain, make sense of the rate law. After such a mechanism is postulated it is found that it is capable of explaining many other facts related to that reaction. Mechanism is a theory and the sole goal of any theory is to explain, help us make sense of facts observed. Therefore, please avoid using the term clues to the mechanism. The rate law is not a clue to the mechanism in the sense that there is some other goal for talking about the mechanism and the rate law becomes one of the clues to achieve this goal. No. The rate law is the very reason for coming up with a possible mechanism which then happens to explain so many other facts. Please replace the term clue with explanation.

]]> By: James https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-547360 Fri, 08 Feb 2019 02:25:30 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-547360 In reply to Amelia.

That’s right, because you’re destroying stereocenters, not making them!

]]> By: Siddarth https://www.masterorganicchemistry.com/2012/09/27/the-e2-mechanism/#comment-531967 Sun, 06 May 2018 18:56:08 +0000 https://www.masterorganicchemistry.com/?p=6041#comment-531967 In reply to Varun.

@Varun this is because the transition state has an alkene-like structure. I am sure of the fact that 3>2>1, but I cannot illustrate the diagram here. You should look it up in a reference book if you still doubt it

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