Comments on: What Makes A Good Leaving Group? https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/ Sat, 02 May 2026 14:11:02 +0000 hourly 1 https://wordpress.org/?v=6.9.4 By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-689604 Thu, 04 Apr 2024 18:51:53 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-689604 In reply to IZERE Benise.

NO2 groups can accept a pi bond from the aromatic ring, making it more electron poor.
https://www.masterorganicchemistry.com/2017/09/26/activating-and-deactivating-groups-in-electrophilic-aromatic-substitution/

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By: IZERE Benise https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-689566 Thu, 04 Apr 2024 05:16:22 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-689566 That’s awesome but I don’t understand why NO2 is meta director while NH2 is Ortho para director

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By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-646620 Mon, 23 Jan 2023 15:59:19 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-646620 In reply to Aayushi.

Glad you found it helpful. Thank you

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By: Aayushi https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-646486 Sat, 21 Jan 2023 13:43:21 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-646486 I used to be quite confused about how I- could be the best nucleophile and the best leaving group at the same time XP
thank you for these explanations!

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By: Bort https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-641702 Wed, 02 Nov 2022 20:38:23 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-641702 H is the least electronegative element. Search its effective nuclear charge. Does it was do be anionic?

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By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-640782 Fri, 21 Oct 2022 20:27:43 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-640782 In reply to Vamsi.

Yes – check out this on nucleophilic aromatic substitution.
https://www.masterorganicchemistry.com/2018/08/20/nucleophilic-aromatic-substitution-nas/

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By: James Ashenhurst https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-640781 Fri, 21 Oct 2022 20:26:48 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-640781 In reply to mycoxsmall.

No. Fluoride ion is a good nucleophile, but is not a good leaving group.

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By: Harsha https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-606593 Mon, 11 Oct 2021 06:32:15 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-606593 Went through many sources..this was really useful!!. Thanks!!!

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By: Rishi https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-599714 Sun, 11 Apr 2021 05:06:26 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-599714 Could you please explain why H- is a strong base
I guess it has noble gas configuration so won’t donate it’s electron
Please clarify.

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By: Michael https://www.masterorganicchemistry.com/2011/04/12/what-makes-a-good-leaving-group/#comment-599642 Thu, 08 Apr 2021 06:06:44 +0000 https://www.masterorganicchemistry.com/?p=1474#comment-599642 If NH3 is more basic than H2O than how is it a Better leaving group than H2O

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