Comments on: Nucleophiles and Electrophiles https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/ Tue, 20 Jan 2026 20:10:55 +0000 hourly 1 https://wordpress.org/?v=6.9.4 By: Shoaai https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-570022 Wed, 06 Nov 2019 20:33:47 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-570022 What the hell is carbon cation, Hmmmm Open Octet, Where ‘s the fourth electron gone,
but excellent posts, Thnx

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By: James Ashenhurst https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-563957 Fri, 13 Sep 2019 16:10:56 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-563957 In reply to Vaishali.

Nucleophile: “nucleus-loving” , i.e. “positive-charge loving”. Electrophile = “electron-loving” i.e. “negative-charge loving”.

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By: James Ashenhurst https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-555295 Wed, 15 May 2019 02:48:27 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-555295 In reply to Asutosh.

They are all electrophilic. The proton of H3O+ is electrophilic. The nitrogen of NO2+ is electrophilic. And the empty p orbital of BH3 is electrophilic. Don’t know where you got this question.

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By: James Ashenhurst https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-555168 Mon, 13 May 2019 16:11:42 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-555168 In reply to Hayat.

Glad to hear it Hayat!

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By: James Ashenhurst https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-551997 Tue, 09 Apr 2019 16:43:45 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-551997 In reply to Suzie.

Well, the “most electrophilic” site would be the atoms directly connected to the most electronegative atom, which is nitrogen. so the carbons will be partially delta positive as will be the hydrogen attached to nitrogen. However in practice diethylamine is an extremely poor electrophile. The only way to make it behave like an electrophile is to add a Lewis acid to the nitrogen or to convert it into an alkylammonium salt with something like CH3I, which will make the nitrogen a much better leaving group.

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By: Suzie https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-548627 Tue, 05 Mar 2019 00:52:04 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-548627 For this compound, CH3CH2NHCH2CH3, where would the electrophilic site be?

Thank you!

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By: James Ashenhurst https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-547546 Mon, 11 Feb 2019 16:27:42 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-547546 In reply to Harshul kamboj.

You are welcome!

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By: Harshul kamboj https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-546988 Thu, 31 Jan 2019 06:56:42 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-546988 Tnq…..for making the concepts easier and clear…!!!

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By: NS https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-546690 Wed, 23 Jan 2019 17:23:55 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-546690 Yes, there are. Many molecules can be both nucleophiles and electrophiles. How they behave, determines whether they are electrophile or neutrophile.
Ex : Water/H2O
If water is reacted with an electrophile,
the water will behave as a nucleophile.
If water is reacted with an neutrophile,
the water will behave as a electrophile.

(* The oxygen atom of water has two lone pairs and a d- charge (oxygen is more electronegative than hydrogen). This suggests that water can behave an a nucleophile. Each hydrogen atom bears a d+ charge, so the molecule can behave as an electrophile as well.) *Quoted

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By: ritu https://www.masterorganicchemistry.com/2012/06/05/nucleophiles-and-electrophiles/#comment-450709 Fri, 18 Mar 2016 18:53:32 +0000 https://www.masterorganicchemistry.com/?p=5227#comment-450709 In reply to Agustin.

hey augustin,
basically it is happens lyk..the grp with a large hydrocarbon part comes out to b a good electron donating grp. In general, electron donating grps such as -ch3 , -och3, -nh2 etc. increase the basicity while electron withdrawing substituents such as -NO2 , CN ,-COOH , -X , decrease the basicity .

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