Comments for Master Organic Chemistry

Comment on Ortho-, Para- and Meta- Directors in Electrophilic Aromatic Substitution by James Ashenhurst

James Ashenhurst — Mon, 25 May 2026 23:40:54 +0000

In reply to shubham. Yes....

Comment on Ionic and Covalent Bonding by Kyro

Kyro — Mon, 25 May 2026 22:44:36 +0000

Thank you for making learning organic chemistry free! its my dream subject to learn even though I am grade 6 :)

Comment on Ortho-, Para- and Meta- Directors in Electrophilic Aromatic Substitution by shubham

shubham — Sun, 24 May 2026 08:42:49 +0000

toulene is ortho-para directing yet activating

Comment on Enolates – Formation, Stability, and Simple Reactions by Enolate Ion: Definition, Structure, Formation, and Properties

Enolate Ion: Definition, Structure, Formation, and Properties — Fri, 22 May 2026 14:52:33 +0000

[…] Masterorganicchemistry.com […]

Comment on Dipole Moments and Dipoles by ALI GODANA

ALI GODANA — Thu, 21 May 2026 06:36:52 +0000

Thanks alot
Well explained

Comment on Carbonyl Chemistry: Learn Six Mechanisms For the Price Of One by BONIFACE

BONIFACE — Thu, 21 May 2026 06:14:02 +0000

ORGANIC CHEMISTRY mechanisms is simplified here where by one can understand in just a second thank you for the good work
i would like to know why why Carboxylic acid is a stronger acid than alcohol

Comment on Alcohols – Nomenclature and Properties by Interesting Facts of Chemistry – StoryTellorian

Interesting Facts of Chemistry – StoryTellorian — Thu, 21 May 2026 00:50:11 +0000

[…] Ashenhurst, J. (2014, September 17). Alcohols (1) – Nomenclature and Properties. Master Organic Chemistry. https://www.masterorganicchemistry.com/2014/09/17/alcohols-1-nomenclature-and-properties/ […]

Comment on m-CPBA (meta-chloroperoxybenzoic acid) by James Ashenhurst

James Ashenhurst — Wed, 20 May 2026 00:24:35 +0000

In reply to X.O..

There’s free rotation about the bond, so it can be drawn in many different ways and is still equivalent.

Like drawing a stick figure of a person with an arm up instead of arm down. Still the same person, it’s just that the arm can move.

Comment on Claisen Condensation and Dieckmann Condensation by James Ashenhurst

James Ashenhurst — Wed, 20 May 2026 00:23:38 +0000

In reply to Char.

What’s the literature reference?

How old is your NaOEt? There’s nothing wrong with making it in situ.

The one thing I’m a little surprised at is that there isn’t more beta elimination of CH3S(-) from the ester enolate. It’s a considerably weaker base than the ester enolate after all.

Comment on Claisen Condensation and Dieckmann Condensation by Char

Char — Tue, 19 May 2026 11:25:13 +0000

This is an excellent popular science piece that has benefited me greatly. I am attempting to reproduce a reaction reported in a 1957 paper. The procedure described therein involves the Claisen condensation of methyl 3-(methylthio)propanoate CH3SCH3CH2COOCH3 with diethyl oxalate using sodium alkoxide, followed by acidic hydrolysis to produce α-ketomethionine CH3SCH2CH2COCOOH.
However, I have failed to replicate the experiment successfully, with barely any consumption of the starting material observed. The sodium ethoxide adopted by the original author was prepared in situ from ethanol and metallic sodium, whereas I used commercially available sodium ethoxide. I suspect the insufficient basicity of sodium ethoxide leads to the poor reaction performance, and I intend to try LDA or NaH for further trials. Could you kindly tell me the possible underlying causes?