Comments on: Aromatic Synthesis (1) – “Order Of Operations” https://www.masterorganicchemistry.com/2018/10/15/aromatic-synthesis-1-order-of-operations/ Mon, 04 May 2026 19:19:02 +0000 hourly 1 https://wordpress.org/?v=6.9.4 By: James Ashenhurst https://www.masterorganicchemistry.com/2018/10/15/aromatic-synthesis-1-order-of-operations/#comment-793600 Mon, 04 May 2026 19:19:02 +0000 https://www.masterorganicchemistry.com/?p=11963#comment-793600 In reply to isabelle du plessis.

Yes, because a straight alkyl chain will rearrange to give the isopropyl in that case. That’s why you should do the “Friedel Crafts Workaround” – FC acylation followed by clemmensen or wolff kishner

]]> By: isabelle du plessis https://www.masterorganicchemistry.com/2018/10/15/aromatic-synthesis-1-order-of-operations/#comment-793588 Mon, 04 May 2026 14:49:29 +0000 https://www.masterorganicchemistry.com/?p=11963#comment-793588 For the last question, how come you can’t do friedel crafts alkylation? i did Ch3CH2Ch2Cl + AlCl3 to get the alkyl chain on the benzene ring and then chlorinated with FeCl3 to get the chlorine in the para position. is acylation a better way to incorporate an alkyl chain?

]]> By: Shelley Gupta https://www.masterorganicchemistry.com/2018/10/15/aromatic-synthesis-1-order-of-operations/#comment-641716 Thu, 03 Nov 2022 06:04:04 +0000 https://www.masterorganicchemistry.com/?p=11963#comment-641716 Very helpful. Thankyou

]]> By: Organophem https://www.masterorganicchemistry.com/2018/10/15/aromatic-synthesis-1-order-of-operations/#comment-581915 Sat, 04 Jul 2020 16:29:01 +0000 https://www.masterorganicchemistry.com/?p=11963#comment-581915 You are too much a genius. You rocks! Can’t thank you enough.

]]> By: Somansh https://www.masterorganicchemistry.com/2018/10/15/aromatic-synthesis-1-order-of-operations/#comment-580297 Sun, 17 May 2020 19:08:18 +0000 https://www.masterorganicchemistry.com/?p=11963#comment-580297 I am IIT-JEE aspirants , and seriously man this website is very useful to use
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